Exercise improves efficacy of levodopa in patients with Parkinson's disease
Identifieur interne : 002E50 ( Main/Exploration ); précédent : 002E49; suivant : 002E51Exercise improves efficacy of levodopa in patients with Parkinson's disease
Auteurs : Siegfried Muhlack [Allemagne] ; Jacub Welnic [Allemagne] ; Dirk Woitalla [Allemagne] ; Thomas Müller [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Area Under Curve, Exercise, Human, Humans, Levodopa, Levodopa (therapeutic use), Male, Middle Aged, Nervous system diseases, Parkinson disease, Parkinsonian Disorders (blood), Parkinsonian Disorders (therapy), Parkinson’s disease, Physical exercise, Severity of Illness Index, Time Factors, efficacy, exercise, levodopa.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood : Parkinsonian Disorders.
- therapy : Parkinsonian Disorders.
- Aged, Area Under Curve, Exercise, Humans, Male, Middle Aged, Severity of Illness Index, Time Factors.
Abstract
The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinson‘s disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the same procedure only at rest on the second day. LD plasma behavior did not significantly differ between both conditions, but the motor response was significantly better 120 and 150 min after LD intake on the day with exercise than on the day with rest. Moderate exercise increases clinical efficacy of LD. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21346
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-02-15">2007-02-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="427">427</biblScope><biblScope unit="page" to="430">430</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A68401E0E57F12646BA01604400BF96AD993316F</idno><idno type="DOI">10.1002/mds.21346</idno><idno type="ArticleID">MDS21346</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Area Under Curve</term><term>Exercise</term><term>Human</term><term>Humans</term><term>Levodopa</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinsonian Disorders (blood)</term><term>Parkinsonian Disorders (therapy)</term><term>Parkinson’s disease</term><term>Physical exercise</term><term>Severity of Illness Index</term><term>Time Factors</term><term>efficacy</term><term>exercise</term><term>levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Area Under Curve</term><term>Exercise</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Exercice physique</term><term>Homme</term><term>Lévodopa</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinson‘s disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the same procedure only at rest on the second day. LD plasma behavior did not significantly differ between both conditions, but the motor response was significantly better 120 and 150 min after LD intake on the day with exercise than on the day with rest. 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